One year after the events of Destiny: Rise of Iron, the Red Legion faction of the Cabal, a military-industrial empire of massive amphibians, attack The Last City with overwhelming forces, led by their leader, Dominus Ghaul. Ghaul, believing the Traveler was wrong in giving humanity Light, succeeds in stripping the Guardians of their powers and forcing them to flee the Tower. Scattered and powerless, the Guardians must acquire new powers to face Ghaul and the Red Legion, venture to new worlds in the Destiny universe, and reclaim the Last City.